If you are using high-quality CBD products you should know that with organic hemp oil, there are rarely anything that you can’t do. The substance doesn’t affect your daily routine, on the contrary, it relieves pain and anxiety and helps you focus and feel calm and relaxed when doing your daily tasks.
However, when we talk about what you shouldn’t do exactly, we mean what other substances you shouldn’t mix with CBD. If you are looking for excellent quality organic CBD products, check Botanicam. If you want to know what you shouldn’t do when on CBD and how it relates to our metabolism, continue reading this article.
The Benefits of CBD
In recent years, cannabidiol (CBD) has gained popularity as numerous studies have been conducted that show its wide-ranging therapeutic effects, as well as that it relieves many symptoms safely and effectively (as it isn’t harmful to our body). Unlike cannabidiol, the other most abundant phytocannabinoid in the cannabis plant, tetrahydrocannabinol (THC), it isn’t intoxicating and psychoactive.
In addition to epileptic seizures, hemp oil has been found to help relieve symptoms of anxiety, depression, inflammatory and neuropathic pain, Parkinson’s disease, Crohn’s disease, and other forms of inflammatory bowel disease, as well as some cancers.
Although the World Health Organization (WHO) has categorized CBD oil with a high threshold of safety for use, it is a very powerful compound that interacts with many different systems in our body. Therefore, CBD is an effective therapeutic agent, but it can also be dangerous when combined with other substances, such as pharmaceutical drugs. Let’s find out why.
Understanding Our Body’s Metabolism
To summarize CBD drug interactions, first, we need to understand how the body’s metabolism works, the aspects involved in CBD metabolism, how CBD is metabolized, and how CBD affects this thing in the body called the cytochrome P-450 system.
What is metabolism?
Metabolic rate is often referred to as a factor that affects how easily or quickly a person gains or loses weight. Scientifically speaking, this is known as basal metabolic rate, or how many calories a person needs to function normally at rest.
Basal metabolic rate is not the same as metabolic rate. Metabolic rate is the process by which food is broken down and absorbed by our body, and to a large extent, this takes place in the intestines and liver through the “first pass” effect. Simply put, the liver breaks down food into its constituent compounds so the body can use it.
Carbohydrates get broken down into sugar, fats into triglycerides, and protein into amino acids. The body’s metabolism converts these compounds into metabolites under the control of enzymes, which then serve as fuel for cellular processes and building blocks for tissues and organs.
Just as food has to undergo this process, so does CBD, but in a very specialized form called drug metabolism. If a drug enters the body, the rate at which it breaks down into metabolites, and the time these metabolites remain in the body, is known as “drug metabolism.” Therefore, CBD ingested orally, whether in oil, tincture, pill, capsule, or other edible forms, passes through the digestive system before entering the bloodstream through the intestines.
CBD then travels to the liver via the blood and enters through the hepatic portal. When CBD enters the liver, enzymes break it down into metabolites. Only after this metabolization can CBD circulate in our blood.
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Different drugs are absorbed by our body differently, and the metabolic rate is different for each one. That’s why it is important not to mix CBD with drugs, you shouldn’t mix it. Always consult with your doctor before taking CBD with strong medication.
The Cytochrome P450 system
It plays a vital role in the detoxification and excretion of foreign drugs (so-called Xenobiotics), as well as other types of toxic substances, in addition to the breakdown of compounds into metabolites.That’s done through a system called “the cytochrome P450 (CYP) system”.
This system consists of several enzymes that include heme as a cofactor to process fat-soluble compounds into water-soluble ones, aiding their absorption. Over 60% of the consumed drug gets metabolized by the CYP system.
Scientists can accurately calculate a dose by using the average time a drug takes to be processed by CYP, but only if a therapeutic compound is processed by the liver and the system as a whole is healthy. It is important to note, however, that there are some compounds that can affect the CYP system, such as CBD, causing certain drugs to be metabolized faster or slower than usual.
CBD and Cytochrome P450
CBD may directly interact with the hepatic CYP system. Preclinical studies show that CBD inhibits CYP enzyme activity by binding to the enzyme site and replacing competing chemical compounds, thereby inhibiting the metabolism of other chemical compounds. The amount of CBD you consume, how you metabolize it, and the type of CBD product you use will affect how CBD inhibits cytochrome P450 and binding proteins. That means CBD ranks first when it comes to being metabolized by CYP enzymes compared to other drugs.
To Sum it Up…
Because CBD interacts with our nervous system, our brain, and our muscles but also with our metabolism. If you have been taking other drugs with CBD can become potentially dangerous for your body, and you may feel different physical consequences. It is best to contact your doctor before you decide to take CBD and mix it with other medication.